Non-profit-making, private and independent
introduced by Roberto SatolliFor over half a century the Istituto Mario Negri has had a unique role in the Italian panorama, and with Silvio Garattini the original idea behind it continues to demonstrate its innovative force. In the same space of time, medicine has experienced unprecedented development in terms of knowledge and efficacy, leading to genuine miracles for global health. However, it has also undergone radical transformation, as profit became the main driving force in its growth. In this framework, the lasting success of Mario Negri reminds us that model dominating today is not the only one possible, nor perhaps the best.